RSPCA: Laboratory animals spared suffering thanks to new test on artificial skin

Tuesday, 10 August 2010 12:00 AM

The RSPCA welcomes news that artificial human skin can now be used to test chemicals for irritation, saving hundreds of laboratory rabbits from suffering and distress.

Not only is the use of this new method more humane, it also provides a more accurate assessment of the potential irritancy of a substance to human skin.

A new guideline from the Organisation for Economic Co-operation and Development (OECD) allows the new test using artificial human skin to establish if a chemical may cause skin irritation*.The new test, which does not involve any testing on animals, replaces one used since the 1940s where chemicals are tested by applying them to rabbits' shaved backs.

Milestone in the replacement of animal tests

RSPCA senior scientist Barry Phillips said: "This is a milestone in the replacement of animal tests with humane alternatives. However, there are still some loopholes which allow regulatory authorities to insist on animal tests for skin irritancy, and these must be closed.

"It has taken more than 25 years of effort by scientists and animal protection groups to develop and gain acceptance for this new method. Much of this time was taken up with proving that the new test works and with persuading regulators and the OECD to accept it.

Resistance to change

"This highlights how many obstacles have to be overcome to replace animal tests with humane alternatives, and illustrates how much resistance to change there is in the area of safety testing. The RSPCA will continue to lobby for the replacement of animals in all areas of research and testing."

More than 5,000 chemical irritancy tests were carried out on rabbits annually in the late 1990s. This reduced to 455 by 2009. This was because of an increased use of non-animal tests, but until now rabbits have continued to be used to check chemicals that appear to be non-irritating during non-animal tests.

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Notes to editors:

- *The OECD produces guidelines setting out how the safety of chemicals should be tested within its 31 member nations. These guidelines are also followed by other countries throughout most of the world. The new guideline was approved by the OECD on Thursday 22 July 2010.

- The artificial human skin consists of a three-dimensional layer that closely mimics the properties of human skin. It is created using waste human tissue removed from patients during certain surgical procedures. Substances can be applied to this skin model to assess their potential to cause skin damage when used in industry or by consumers.

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